In 2006, Andrew Fire and Craig Mello shared the Nobel Prize in Physiology or Medicine for their discovery of RNA interference (RNAi), which they published in 1998. Since then, the potential of a technology capable of silencing disease-causing genes has been a very attractive proposition.
When bear market losses occur, headlines talk in percentages: “The market dropped 20 %.” Investors nod. A 20 % decline sounds manageable, historical, and expected.
Many investors have turned to MLPs over the years for their income, which makes the outlook for distributions a perennial focus for investors. With MLP yields currently elevated relative to long-term averages and a flattish near-term outlook for U.S. energy production, the distribution outlook is particularly topical.
Over the next decade, almost every rich country will have to face fiscal reality. All have expanded their welfare state to serve not only the needy but also the middle class, with expensive pensions, health care and worker benefits.
Some political commentators believe Stephen Miran is a pawn of President Trump, aiming solely to lower interest rates, regardless of whether such action is justified. But, regardless of your political views, set aside your own perspectives for a moment and consider Miran’s views on the economy and monetary policy.
In this article, I will discuss the process financial advisors can follow to help their clients determine how much they should initially set aside for LTC and how to periodically monitor whether the amount their clients have set aside (the reserve) continues to be sufficient in the future.
OpenAI may not be publicly traded, but the world’s most valuable startup is increasingly making waves in the stock market.
Over the past three years, the economic conversation has been a “promised recession.” If you read the headlines, tracked economist surveys, or even listened to Wall Street strategists, you would have assumed a downturn was imminent. And yet, here we are, late into 2025, and the U.S. economy is still standing.
From harvesting pollen for industrial use to commercially available drone delivery to osmotic power plants—Franklin Equity Group’s Matt Moberg highlights some of the most exciting innovations in the latest “Innovation Insights Quarterly.”
Debt is a curse that can also be a blessing, depending on how the borrower uses it. Sadly, human nature seemingly ensures we often use debt unproductively—and not just as individuals. Governments have their own special way of using debt to buy benefits (and votes?) today that future generations will pay for.
The newest member of the Federal Reserve Board, Stephen Miran, recently outlined his reasons for wanting interest rates to come down by roughly 2 percentage points—far more than any other Fed member.
Should the US Federal Reserve keep cutting interest rates? Markets certainly think it will: Futures prices suggest the federal funds rate will fall to about 3% by the end of 2026, from just above 4% now.
Overfunded pension plans don't have to die—they can live on in a 401(k) plan.
For more than two decades, US money managers have looked on enviously as Vanguard Group reaped the benefits of a unique structure that grafted the advantages of an ETF onto its biggest mutual funds.
Fall is here, making now an ideal time to address your year-end financial goals and begin mapping out new goals for the year ahead. Sequoia’s Special Needs Financial Planning team is a comprehensive financial planning partner, ready to support you on multiple fronts.
In this video, Chuck Carnevale, co-founder of FAST Graphs, dives deep into Comcast (CMCSA) to evaluate whether today’s low stock price represents risk or opportunity.
Advisors who want to grow a family office business need to make sure they have the expertise and resources to service the far-ranging needs of wealthy families. Some wealthy families are looking for a “one-stop solution.
Here are some key areas of focus as you think about solidifying your current team or preparing to transition and join a new team.
When it comes to managing risk, OCIO providers can’t afford to overlook history.
Changing CEOs won’t change the fact that the decision to pursue a merger lies with BNSF and Berkshire. Buffett and his management team are unlikely to be impressed by threats of proxy fights nor shareholder-activist bullies.
Over 60% of small cap investors use passive funds, but we strongly believe this is a missed opportunity, as small caps have consistently been one of the most reliable sources of alpha available in the public markets.
While it may seem that way at extremes, momentum tends to exhaust, and reversals or corrections become more probable. The RSI gives us a real-time gauge of when a trend may be vulnerable to a pullback or turn.
Always intense, the perennial debate over whether equities are too richly valued has become even more fervent of late.
On this week’s edition of Market Week in Review, Senior Investment Strategist and Head of Canadian Strategy, BeiChen Lin, assessed the health of the U.S. economy. He also explained why the Swiss National Bank held the line on monetary policy and discussed the potential market impacts of a U.S. government shutdown.
Goodbye summer, hello fall! As the sun sets on another season, we’re swapping beach days and backyard barbeques for crisp mornings, vibrant foliage, football weekends, and everything pumpkin spice.
My reasons are simple. The debt pile is unfathomably massive, and it’s accelerating. Fiscal imbalances are widening, and monetary policy is being constrained. The Fed can’t raise rates aggressively without bankrupting the government, but it also can’t make deep cuts without tanking the dollar.
For an industry that’s only just getting started, there’s a lot of hype around humanoid robots.
VettaFi’s Head of Research Todd Rosenbluth discussed the Fidelity Investment Grade Securitized ETF (FSEC) on this week’s “ETF of the Week” podcast with Chuck Jaffe of “Money Life.”
Some Wall Street pundits believe that the recent Fed rate cut makes its policy too accommodative, and they also argue that the Fed is creating a “Goldilocks” scenario for the stock market. To better gauge where policy lies on the accommodative to restrictive spectrum, it's critical to compare the policy to current economic growth and inflation rates.
It’s not all bad news for the the UK stock market. AstraZeneca Plc has found a clever way of becoming a US-listed company without going all-American.
For years, midstream companies have generated significant free cash flow (FCF), which has differentiated them from the broader market. With balance sheets in good shape, excess cash has been used to reward shareholders with dividend growth and opportunistic equity repurchases
Cybersecurity continues to grab consistent media attention as hackers become increasingly emboldened. They’re also more ambitious in terms of targets, many of which are familiar companies behind goods and services consumed by Americans on a daily basis.
Tech builders love a good feedback loop, and Nvidia Corp. and OpenAI have created a $100 billion one this week.
Treasury Inflation-Protected Securities, or TIPS, can help buffer a portfolio against inflation. However, it's important to understand their unique characteristics and complex nature.
Clearer policy and lower rates are favorable for growth.
This article is part of a series exploring two complementary investment themes. The ROBO Global Artificial Intelligence Index (THNQ) captures the digital AI ecosystem, including AI-semiconductors, cloud infrastructure, cybersecurity, connectivity, and applications.
Many people are puzzled about the disconnect between how well the US economy is doing and how badly Americans feel about it.
A pair of senior Goldman Sachs Group Inc. executives are betting that Europe’s long-awaited revival in infrastructure spending and dealmaking will help power regional growth at the Wall Street bank.
In a commoditized industry where every advisor offers similar tools and services, the real differentiator is how you make clients feel. Emotional security is such a differentiator. It makes clients feel heard, prepared and reassured. It drives client loyalty, retention and referrals.
Content marketing isn’t a short-term play; it’s a system that compounds over time. By building a consistent, strategic content plan, you position your firm to attract, nurture, and convert more of your ideal clients year after year.
With German fiscal spending rising, interest rates low and reforms continuing, European value stocks have the potential to shine despite the current political uncertainties, says Franklin Mutual Series.
While the last 12 months were profoundly shaped by the incoming Trump administration’s DOGE program, tariffs, immigration and foreign policy, what hasn't changed over the last year is that the bond market still represents good value despite policy initiatives that cloud the outlook: “We think the Fed is poised to ease, given weak employment reports,” Pierson said.
In an interesting but problematic new book, After the Spike: Population, Progress, and the Case for People, two economists, Dean Spears and Michael Geruso, warn that the switch to a population implosion, currently underway, could have catastrophic consequences for human well-being and even survival.
One of the most critical resources in 2025 is compute power. Chips and the data centers that house them have become the 21st-century equivalent of refineries and power plants, and governments are increasingly treating them as such.
To understand where the market might go, you need to weigh both the bull case and bear case in light of what is actually priced and what risks remain unacknowledged. The data support the bull momentum case, but many components are already baked into current prices.
At BlackRock Inc., PGIM and other Wall Street firms, bond-fund managers are sticking to trades that will likely pay off even if the Federal Reserve’s path is again knocked off course by surprising turns in the economy.
Senior Investment Strategist and Head of Canadian Strategy, BeiChen Lin, unpacked the latest rate decisions from major central banks. He also assessed the health of the U.S. housing market and potential opportunities in listed real estate.
The Federal Reserve’s September meeting may be remembered less for the modest quarter-point cut it delivered and more for what it revealed about the state of the institution itself.
Target date funds represent the investment industry's best thinking about how people should invest for retirement.
The Federal Reserve cut rates by 0.25% today, citing a rising risk to the employment side of their dual mandate. While that was no surprise, there were many questions on where the Fed would go from here, and what it would take to accelerate or slow the pace of policy adjustment.
